While not a cure-all, spermidine has undeniable benefits for holistic health. With effects ranging from disease protection to hair health, and applications in areas as diverse as coronavirus and fertility, regularly taking spermidine supplements can boost the health and longevity effects of a healthy lifestyle.
Safety and side-effects
Considering spermidine is a naturally occurring product in the body, it is considered very safe for health. In addition, clinical trials have shown that the supplement has no known side effects.
Health and longevity benefits
Longevity supplements can be used as part of a balanced diet and regular exercise to unlock health and longevity. Increasing spermidine intake can reduce the risk of many age-related diseases, such as cancer, metabolic diseases, heart disease and neurodegenerative diseases. It can also improve cognition and memory. Spermidine has a neuroprotective effect on neuronal damage caused by inflammation, ischemia and oxidative stress. One way it does this is by dissolving beta-amyloid through autophagy. These plaques can build up in the brain and are thought to be linked to neurodegenerative diseases such as Alzheimer’s. In fact, one study showed that spermidine can prevent memory loss in alzheimer’s patients. A daily spermidine supplement could be a promising tool in the fight against age-related diseases in a rapidly growing aging population.
Spermidine itself may also contribute to longevity. The supplement mimics other life-extending interventions, such as calorie restriction and promoting cell renewal through autophagy. Spermidine also protects DNA from damage caused by oxidative stress. It has been observed to stabilize mitochondrial DNA, thereby preventing aging caused by mutations in the mitochondrial genome. It also prevented telomere fraying, the end of chromosomes that shorten with age, directly affecting longevity in mice. Genomic instability and telomere shortening are both part of the markers of aging, biomarkers that measure how organisms change as they age. Research has shown that spermidine suppresses five of the nine markers of aging.
Based on anti-aging wisdom from ancient Japanese medical books, the supplement combines spermidine and the active ingredients of wheat germ to reduce deep wrinkles and promote hair growth, longer eyelashes and stronger nails by producing keratin, all of which contribute to a more youthful appearance. In fact, one study demonstrated spermidine’s anti-aging effects on the skin.